Mark McGilchrist
Professeur associé au département de médecine à l’Université de Sherbrooke
Chercheur sénior en informatique de la santé à l’Université de Dundee (Écosse)
Chercheur associé sénior à l’Université de Dundee (Écosse), Mark McGilchrist collabore avec les membres du GRIIS sur des projets d’infrastructures automatisées pour les essais cliniques, les études observationnelles et l’aide à la décision. Physicien de formation (Université de Cambridge), il s’est tourné vers l’informatique de la santé en 1989 à l’Université de Dundee où il avait accès à plusieurs sources de données de routine. Au cours de ses 30 années de carrière en informatique de la santé, il s’est concentré sur les méthodes, systèmes et interfaces permettant l’utilisation secondaire de données de routine populationnelles. Grâce à cette approche et à son expérience dans une variété de systèmes d’informations, il contribue à générer des connaissances qui améliorent la santé et la qualité de vie des individus et des populations.
Les travaux de recherche de Mark McGilchrist touchent principalement aux soins de santé et aux services sociaux. Il s’intéresse aussi à diverses sphères sociales comme l’éducation, le droit et l’application des lois. Son champ d’expertise englobe les techniques de couplage de documents ainsi que les modèles, normes et algorithmes servant aux essais cliniques, aux études observationnelles (incluant le suivi des médicaments après leur mise en marché) et aux outils d’aide à la décision. Il a été un contributeur de premier plan lors de la création de biobanques régionales et nationales. Il a participé à des projets internationaux d’envergure (p. ex. EU FP7 et EU IMI).
Formation
Ph. D., Université de Cambridge (R.-U.), physique
M.A., Université de Cambridge (R.-U.), physique
Publications
Ecarot T, Fraikin B, Lavoie L, McGilchrist M, Ethier J-F (2021) A Sensitive Data Access Model in Support of Learning Health Systems. Computers 10:25. https://doi.org/10.3390/computers10030025 Cite Download
Barma MA, Soiza RL, Donnan PT, McGilchrist MM, Frost H, Witham MD (2018) Serum sodium level variability as a prognosticator in older adults. Scand J Clin Lab Invest 78:632–638. https://doi.org/10.1080/00365513.2018.1543893 Cite Download
Verheij RA, Curcin V, Delaney BC, McGilchrist MM (2018) Possible sources of bias in primary care electronic health record data use and reuse. J Med Internet Res 20:e185. Cite
Ethier J-F, McGilchrist MM, Barton A, Cloutier A-M, Curcin V, Delaney BC, Burgun A (2018) The TRANSFoRm project: Experience and lessons learned regarding functional and interoperability requirements to support primary care. Learn Health Syst 2:e10037. https://doi.org/10.1002/lrh2.10037 Cite Download
Ethier J-F, Curcin V, McGilchrist MM, Lim Choi Keung SN, Zhao L, Andreasson A, Bródka P, Michalski R, Arvanitis TN, Mastellos N, Burgun A, Delaney BC (2017) eSource for clinical trials: Implementation and evaluation of a standards-based approach in a real world trial. Int J Med Inform 106:17–24. https://doi.org/10.1016/j.ijmedinf.2017.06.006 Cite Download Download
Goodbrand JA, Hughes LD, Cochrane L, Donnan PT, McGilchrist MM, Frost H, McMurdo MET, Witham MD (2017) Association between bisphosphonate therapy and outcomes from rehabilitation in older people. Arch Gerontol Geriatr 70:195–200. https://doi.org/10.1016/j.archger.2017.01.017 Cite Download
Hinney A, Kesselmeier M, Jall S, Volckmar A-L, Föcker M, Antel J, Perica VB, Franklin CS, Floyd JAB, Thornton LM, Huckins LM, Southam L, Rayner NW, Tachmazidou I, Klump KL, Treasure J, Lewis CM, Schmidt U, Tozzi F, iezebrink K, Hebebrand J, Gorwood P, Adan RAH, Kas MJH, Favaro A, Santonastaso P, Fernández-Aranda F, Gratacos M, Rybakowski F, Dmitrzak-Weglarz M, Kaprio J, Keski-Rahkonen A, Raevuori-Helkamaa A, Van Furth EF, Slof-Op't Landt MCT, Hudson JI, Reichborn-Kjennerud T, Knudsen GPS, Monteleone P, Kaplan AS, Karwautz A, Hakonarson H, Berrettini WH, Guo Y, Li D, Schork NJ, Komaki G, Ando T, Inoko H, Esko T, Fischer K, Männik K, Metspalu A, Baker JH, Cone RD, Dackor J, DeSocio JE, Hilliard CE, O'Toole JK, Pantel J, Szatkiewicz JP, Taico C, Zerwas S, Trace SE, Davis OSP, Helder S, Bühren K, Burghardt R, de Zwaan M, Egberts K, Ehrlich S, Herpertz-Dahlmann B, Herzog W, Imgart H, Scherag A, Scherag S, Zipfel S, Boni C, Ramoz N, Versini A, Brandys MK, Danner UN, de Kove C, Hendriks J, Koeleman BPC, Ophoff RA, Strengman E, van Elburg AA, Bruson A, Clementi M, Degortes D, Forzan M, Tenconi E, Docampo E, Escaramí G, Jiménez-Murcia S, Lissowska J, Rajewski A, Szeszenia-Dabrowska N, Slopien A, Hauser J, Karhunen L, Meulenbelt I, Slagboom PE, Tortorella A, Maj M, Dedoussis G, Dikeos D, Gonidakis F, Tziouvas K, Tsitsika A, Papezova H, Slachtova L, Martaskova D, Kennedy JL, Levitan RD, Yilmaz Z, Huemer J, Koubek D, Merl E, Wagner G, Lichtenstein P, Breen G, Cohen-Woods S, Farmer A, McGuffin P, Cichon S, Giegling I, Herms S, Rujescu D, Schreiber S, Wichmann H-E, Dina C, Sladek R, Gambaro G, Soranzo N, Julia A, Marsal S, Rabionet R, Gaborieau V, Dick DM, Palotie A, Ripatti S, Widén E, Andreassen OA, Espeseth T, Lundervold A, Reinvang I, Steen VM, Hellard SL, Mattingsdal M, Ntalla I, Bencko V, Foretova L, Janout V, Navratilova M, Gallinger S, Pinto D, Scherer SW, Aschauer H, Carlberg L, Schosser A, Alfredsson L, Ding B, Klareskog L, Padyukov L, Finan C, Kalsi G, Roberts M, Logan DW, Peltonen L, Ritchie GRS, Barrett JC, Estivill X, Hinney A, Sullivan PF, Collier DA, Zeggini E, Bulik CM, Anderson CA, Barrett JC, Floyd JAB, Franklin CS, McGinnis R, Soranzo N, Zeggini E, Sambrook J, Stephens J, Ouwehand WH, McArdle WL, Ring SM, Strachan DP, Alexander G, Bulik CM, Collier DA, Conlon PJ, Dominiczak A, Duncanson A, Hill A, Langford C, Lord G, Maxwell AP, Morgan L, Peltonen L, Sandford RN, Sheerin N, Vannberg FO, Blackburn H, Chen W-M, Edkins S, Gillman M, Gray E, Hunt SE, Nengut-Gumuscu S, Potter S, Rich SS, Simpkin D, Whittaker P, Heid IM, Winkler TW, de Bakker P, Bültmann U, Geleijnse M, Harst PV, Koppelman G, Rosmalen JG, van Rossum L, Smidt H, Swertz MA, Stolk RP, Alizadeh B, de Boer R, Boezen HM, Bruinenberg M, Franke L, van der Harst P, Hillege H, van der Klauw M, Navis G, Ormel J, Postma D, Rosmalen J, Slaets J, Snieder H, Stolk R, Wolffenbuttel B, Wijmenga C, Berg J, Blackwood D, Campbell H, Cavanagh J, Connell J, Connor M, Cunningham-Burley S, Deary I, Dominiczak A, Ellis P, FitzPatrick B, Ford I, Gertz R, Grau A, Haddow G, Jackson C, Kerr S, Lindsay R, McGilchrist M, McIntyre D, Morris A, Morton R, Muir W, Murray G, Palmer C, Pell J, Philp A, Porteous D, Porteous M, Procter R, Ralston S, Reid D, Sinnott R, Smith B, Clair DS, Sullivan F, Sweetland M, Ure J, Watt G, Wolf R, Wright A, Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau- Chonka DC, GCAN, WTCCC3, GIANT (2017) Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry 22:192–201. Cite Download
Mastellos N, Bliźniuk G, Czopnik D, McGilchrist MM, Misiaszek A, Bródka P, Curcin V, Car J, Delaney BC, Andreasson A (2016) Feasibility and acceptability of TRANSFoRm to improve clinical trial recruitment in primary care. Fam Pract 33:186–191. https://doi.org/10.1093/fampra/cmv102 Cite Download
Basu U, Goodbrand J, McMurdo MET, Donnan PT, McGilchrist MM, Frost H, George J, Witham MD (2016) Association between allopurinol use and hip fracture in older patients. Bone 84:189–193. https://doi.org/10.1016/j.bone.2016.01.003 Cite
Bruland P, McGilchrist MM, Zapletal E, Acosta D, Proeve J, Askin S, Ganslandt T, Doods J, Dugas M (2016) Common data elements for secondary use of electronic health record data for clinical trial execution and serious adverse event reporting. BMC Med Res Methodol 16:159. https://doi.org/10.1186/s12874-016-0259-3 Cite Download
Barma M, Goodbrand JA, Donnan PT, McGilchrist MM, Frost H, McMurdo MET, Witham MD (2016) Slower decline in c-reactive protein after an inflammatory insult is associated with longer survival in older hospitalised patients. PLoS One 11:e0159412. https://doi.org/10.1371/journal.pone.0159412 Cite
Doyle EM, Sloan JM, Goodbrand JA, McMurdo MET, Donnan PT, McGilchrist MM, Frost H, Witham MD (2015) Association between kidney function, rehabilitation outcome, and survival in older patients discharged from inpatient rehabilitation. Am J Kidney Dis 66:768–774. https://doi.org/10.1053/j.ajkd.2015.04.041 Cite
Witham MD, Frost H, McMurdo M, Donnan PT, McGilchrist MM (2015) Construction of a linked health and social care database resource—lessons on process, content and culture. Inform Health Soc Care 40:229–239. Cite
Ethier J-F, Curcin V, Barton A, McGilchrist MM, Bastiaens H, Andreasson A, Rossiter J, Zhao L, Arvanitis TN, Taweel A, Delaney BC, Burgun A (2015) Clinical data integration model: Core interoperability ontology for research using primary care data. Methods Inf Med 54:16–23. https://doi.org/10.3414/ME13-02-0024 Cite Download
Delaney BC, Curcin V, Andreasson A, Arvanitis TN, Bastiaens H, Corrigan D, Ethier J-F, Kostopoulou O, Kuchinke W, McGilchrist MM, van Royen P, Wagner P (2015) Translational medicine and patient safety in Europe: TRANSFoRm—Architecture for the learning health system in Europe. Biomed Res Int 2015:961526. https://doi.org/10.1155/2015/961526 Cite Download
Doods J, Bache R, McGilchrist MM, Daniel C, Dugas M, Fritz F, Work Package 7 (2014) Piloting the EHR4CR feasibility platform across Europe. Methods Inf Med 53:264–268. https://doi.org/10.3414/ME13-01-0134 Cite
Bache R, Daniel C, James J, Hussain S, McGilchrist MM, Delaney B, Taweel A (2014) An approach for utilizing clinical statements in HL7 RIM to evaluate eligibility criteria. Stud Health Technol Inform 205:273–277 Cite
Goodson NJ, Smith BH, Hocking LJ, McGilchrist MM, Dominiczak AF, Morris A, Porteous DJ, Goebel A (2013) Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: results from a cross-sectional general population study. Pain 154:1595–1602. https://doi.org/10.1016/j.pain.2013.04.043 Cite
Smith BH, Campbell A, Linksted P, Fitzpatrick B, Jackson C, Kerr SM, Deary IJ, Macintyre DJ, Campbell H, McGilchrist MM, Hocking LJ, Wisely L, Ford I, Lindsay RS, Morton R, Palmer CNA, Dominiczak AF, Porteous DJ, Morris AD (2013) Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness. International Journal of Epidemiology 42:689–700. Cite Download
Ethier J-F, Dameron O, Curcin V, McGilchrist MM, Verheij RA, Arvanitis TN, Taweel A, Delaney BC, Burgun A (2013) A unified structural/terminological interoperability framework based on LexEVS: application to TRANSFoRm. J Am Med Inform Assoc 20:986–994. https://doi.org/10.1136/amiajnl-2012-001312 Cite Download
de Lusignan S, Krause P, Michalakidis G, Vicente MT, Thompson S, McGilchrist MM, Sullivan F, van Royen P, Agreus L, Desombre T, Taweel A, Delaney B (2012) Business process modelling is an essential part of a requirements analysis: Contribution of EFMI primary care working group. Yearb Med Inform 7:34–43 Cite
Leppenwell E, de Lusignan S, Vicente MT, Michalakidis G, Krause P, Thompson S, McGilchrist MM, Sullivan F, Desombre T, Taweel A, Delaney B (2012) Developing a survey instrument to assess the readiness of primary care data, genetic and disease registries to conduct linked research: TRANSFoRm International Research Readiness (TIRRE) survey instrument. Inform Prim Care 20:207–216 Cite
McLeish NJ, Simmonds P, Robertson C, Handel I, McGilchrist MM, Singh BK, Kerr S, Chase-Topping ME, Sinka K, Bronsvoort M, Porteous DJ, Carman W, McMenamin J, Leigh-Brown A, Woolhouse MEJ (2011) Sero-prevalence and incidence of A/H1N1 2009 influenza infection in Scotland in winter 2009-2010. PLoS ONE 6:e20358. https://doi.org/10.1371/journal.pone.0020358 Cite Download
Macleod AK, Liewald DCM, McGilchrist MM, Morris AD, Kerr SM, Porteous DJ (2009) Some principles and practices of genetic biobanking studies. Eur Respir J 33:419–425. https://doi.org/10.1183/09031936.00043508 Cite
McGilchrist MM, Sullivan F, Kalra D (2007) Assuring the confidentiality of shared electronic health records. BMJ 335:1223–1224. https://doi.org/10.1136/bmj.39421.544063.BE Cite Download
Ure J, Procter R, Martone M, Porteous D, Lloyd S, Lawrie S, Job D, Baldock R, Philp A, Liewald D, Rakebrandt F, Blaikie A, McKay C, Anderson S, Ainsworth J, van Hemert J, Blanquer I, Sinnott R, Barillot C, Gibaud FB, Williams A, Hartswood M, Watson P, Smith L, Burger A, Kennedy J, Gonzalez-Velez H, Stevens R, Corcho O, Morton R, Linksted P, Deschenes M, McGilchrist MM, Johnson P, Voss A, Gertz R, Wardlaw J (2007) Data integration in eHealth: a domain/disease specific roadmap. Stud Health Technol Inform 126:144–153 Cite
Smith BH, Campbell H, Blackwood D, Connell J, Connor M, Deary IJ, Dominiczak AF, Fitzpatrick B, Ford I, Jackson C, Haddow G, Kerr S, Lindsay R, McGilchrist MM, Morton R, Murray G, Palmer CNA, Pell JP, Ralston SH, St Clair D, Sullivan F, Watt G, Wolf R, Wright A, Porteous D, Morris AD (2006) Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability. BMC Med Genet 7:74. https://doi.org/10.1186/1471-2350-7-74 Cite Download
Prach AT, McGilchrist MM, Murray FE, Johnston DA, MacDonald TM (1999) Prescription of acid-suppressing drugs in relation to endoscopic diagnosis: a record-linkage study. Aliment Pharmacol Ther 13:397–405 Cite
McMahon AD, Evans JM, McGilchrist MM, McDevitt DG, MacDonald TM (1998) Drug exposure risk windows and unexposed comparator groups for cohort studies in pharmacoepidemiology. Pharmacoepidemiol Drug Saf 7:275–280. https://doi.org/10.1002/(SICI)1099-1557(199807/08)7:4<275::AID-PDS363>3.0.CO;2-N Cite
MacDonald TM, Parkinson J, Davey PG, Morris AD, McDevitt DG, McGilchrist MM (1998) PACT data for dispensed drugs linked to NHS numbers are available now. BMJ 316:1530. https://doi.org/10.1136/bmj.316.7143.1530a Cite
MacDonald TM, Morant SV, Robinson GC, Shield MJ, McGilchrist MM, Murray FE, McDevitt DG (1997) Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study. BMJ 315:1333–1337. https://doi.org/10.1136/bmj.315.7119.1333 Cite
McMahon AD, Evans JM, White G, Murray FE, McGilchrist MM, McDevitt DG, MacDonald TM (1997) A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation. J Clin Epidemiol 50:351–356 Cite
Millar HL, Clunie FS, McGilchrist MM, McMahon AD, MacDonald TM (1997) The impact on community benzodiazepine prescribing of hospitalization. J Psychosom Res 42:61–69 Cite
Dornan S, Murray FE, White G, McGilchrist MM, Evans JM, McDevitt DG, MacDonald TM (1995) An audit of the accuracy of upper gastrointestinal diagnoses in Scottish Morbidity Record 1 data in Tayside. Health Bull (Edinb) 53:274–279 Cite
Evans JM, McGregor E, McMahon AD, McGilchrist MM, Jones MC, White G, McDevitt DG, MacDonald TM (1995) Non-steroidal anti-inflammatory drugs and hospitalization for acute renal failure. QJM 88:551–557 Cite
Evans JM, McMahon AD, McGilchrist MM, White G, Murray FE, McDevitt DG, MacDonald TM (1995) Topical non-steroidal anti-inflammatory drugs and admission to hospital for upper gastrointestinal bleeding and perforation: a record linkage case-control study. BMJ 311:22–26. https://doi.org/10.1136/bmj.311.6996.22 Cite
MacDonald TM, Collins D, McGilchrist MM, Stevens J, McKendrick AD, McDevitt DG, Davey PG (1995) The utilisation and economic evaluation of antibiotics prescribed in primary care. J Antimicrob Chemother 35:191–204 Cite
Beardon PH, McGilchrist MM, McKendrick AD, McDevitt DG, MacDonald TM (1993) Primary non-compliance with prescribed medication in primary care. BMJ 307:846–848. https://doi.org/10.1136/bmj.307.6908.846 Cite
MacDonald TM, Beardon PH, McGilchrist MM, Duncan ID, McKendrick AD, McDevitt DG (1993) The risks of symptomatic vaginal candidiasis after oral antibiotic therapy. Q J Med 86:419–424 Cite
Ecarot T, Fraikin B, Lavoie L, McGilchrist MM, Ethier J-F (2021) Learning health systems: An anonymous network routing protocol. In: Almeida JR, Gonzalez AR, Shen L, Kane B, Soda P, Oliveira JL (eds) Proceedings of the IEEE Symposium on Computer-Based Medical Systems. pp 562–567 Cite
Lim Choi Keung SN, Zhao L, Arvanitis TN, Curcin V, Delaney BC, Ethier J-F, Burgun A, McGilchrist MM, Bródka P, Tuligowicz W, Andreasson A (2015) TRANSFoRm: Implementing a learning healthcare system in Europe through embedding clinical research into clinical practice. In: 2015 48th Hawaii International Conference on System Sciences. Hawaii, États-Unis, pp 3176–3185 Cite Download
Lim Choi Keung SN, Zhao L, Rossiter J, McGilchrist MM, Culross F, Ethier J-F, Burgun A, Verheij RA, Khan N, Taweel A, Curcin V, Delaney BC, Arvanitis TN (2014) Detailed clinical modelling approach to data extraction from heterogeneous data sources for clinical research. In: AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science. pp 55–59 Cite Download
Ethier J-F, McGilchrist MM, Fabry P (2021) Introduction to Formal Ontologies Cite
Curcin V, Arvanitis TN, Ethier J-F, Fraczkowsk K, Kazienko P, Brodka P, Andreasson A, Blizniuk G, Lim Choi Keung SN, Zhao L, Misiaszek A, McGilchrist MM, Delaney BC, Burgun A (2014) Semantic approach to achieving interoperability between clinical care and clinical research Cite Download
Lim Choi Keung SN, Zhao L, Rossiter J, Ogunsina I, Curcin V, Danger R, McGilchrist MM, Ethier J-F, Ohmann C, Kuchinke W, Taweel A, Delaney BC, Arvanitis TN (2013) Provenance-aware query formulation tool to identify eligible clinical research participants Cite
